COVID-19 Vaccine Based on Measles Vaccine?
A new SARS-CoV-2 vaccine based on the measles vaccine provided effective protection in initial trials. In animal studies, a strong immune response was observed and SARS-CoV-2 infection and lung disease were prevented.
The combination of a measles vaccine could result in a new, effective and safe vaccine for SARS-CoV-2, according to a study by researchers from Ohio State University. The study was published in the Journal of the English Language.Proceedings of the National Academy of SciencesPublished.
What is the effectiveness of the new vaccine based on?
According to the researchers, the efficacy of the novel candidate vaccine is due to the strategic production of the antigen to stimulate immunity. The team used a specific section of the coronavirus spinal protein gene and inserted it into the so-called sweet spot in the measles vaccine genome to increase the activation or expression of the gene that produces the protein.
The measles vaccine is safe
The researchers report that although many vaccines are already on the market, the new candidate vaccine may have benefits worth exploring. This applies in particular to the safety, durability, and high efficacy of the measles vaccine. “The measles vaccine has been used in children since the 1960s and has a long history of safe use in children and adults,” said study author Professor Jianrong Lee of the Department of Veterinary Biological Sciences at Ohio State University.
Long-term protection with measles vaccine?
We also know that the measles vaccine can provide long-lasting protection. The hope is that, with the antigen present in it, it could provide long-lasting protection against SARS-CoV-2. This will be a huge advantage, because at the moment we do not know how long the protection for all vaccine platforms will last, ”the expert adds in one Press release Added.
How does the new vaccine work
The coronavirus that causes COVID-19 uses the prickly protein on its surface to bind to target cells in the nose and lungs. There it makes copies of itself, and it is freed to infect other cells. Like all vaccines, the new vaccine stimulates the production of antibodies that recognize the new protein as foreign and train the immune system to attack and neutralize the spike protein if SARS-CoV-2 enters the body, the researchers explain.
For the research, the team tested seven versions of Spike’s protein to find the most effective antigen. We ended up with a stable precursor of the protein – the form in which the protein is in before it infects the cell, the researchers explain.
What was changed in the measles vaccine?
Those skilled in this field inserted the prickly protein pre-gene, which contains the instructions for making, into a portion of the measles vaccine genome to produce a high-protein expression. The reason the team presented was that the more SARS-CoV-2 protein was produced, the better the immune response.
How does the new vaccine work in animals?
The researchers tested the candidate vaccine in several animal models to assess its effectiveness. They found that the vaccine caused high levels of SARS-CoV-2 neutralizing antibodies in all animals.
Strong antibody reaction
One would assume that the immunity of most people against measles, thanks to decades of widespread vaccination, would render this vaccine unusable as a candidate for the Coronavirus. Therefore, researchers investigated in mice made of cotton whether a second vaccination with the SARS-CoV-2 vaccine based on measles was effective. It turns out that a strong antibody reaction can be evoked.
In response to the vaccine, the transgenic mice produced helper T cells (a type of white blood cell) and other important auxiliaries that the body uses to fight infections and particularly dangerous diseases, experts say.
Increase the safety and effectiveness of the vaccine
Study author Amit Kapoor from Ohio State University said: “The targeting of vaccine-induced T helper cells is an important indicator of protection, and this vaccine mainly stimulates Th1 cells, which increases the safety and efficacy of the vaccine.”
The vaccine has also been given to golden hamsters that are particularly susceptible to COVID-19 infection. Then the animals were infected with the Corona virus. Experts reported that the vaccinated animals were protected from lung infection and other disease symptoms.
When we looked at the amount of neutralizing antibodies stimulated in hamsters, it was actually higher than that found in people with COVID, indicating that the vaccine might induce better protective immunity than SARS-2 infection. “That was our goal,” said study author Mark E. Peebles of The Ohio State University.
Why does the new vaccine have high potential?
Researchers trust the platform not only because the measles vaccine is safe, effective, and inexpensive to manufacture, but also because many experimental vaccines against other viruses are in development. For example, a vaccine against the chikungunya virus, which is transmitted by mosquitoes, was shown to be safe, well tolerated, and well suited for eliciting an immune response in a phase 2 clinical study.
Even with the variety of COVID-19 vaccines now available in the United States and other countries, there is still a lot to learn about which are safest and most effective for specific populations (such as children and pregnant women) and which vaccines are the most economical to produce, experts explain.
Vaccine production in record time?
“We can produce vaccines today much faster than in the past. But if we had to do it the traditional way, we wouldn’t have a vaccine to protect us in such a short time. The mRNA vaccines used now are manufactured in record time, they protect against disease, and they are safe.” Although not at the same speed, we were able to produce this vaccine much faster than the original measles vaccine, “explains study author Stefan Newisk from Ohio State University.
How long will the protective effect last?
“We don’t yet know how long the mRNA vaccines will protect and how much they will cost. Meanwhile, an alternative vaccine that should be long-lasting, easy to make and inexpensive, appears to be a good idea.” (Like)
Author and source information
This text complies with the requirements of the specialized medical literature, medical guidelines and current studies and has been examined by medical professionals.
- Mijia Lu, Piyush Dravid, Yuexiu Zhang, Sheetal Trivedi, Anzhong Li et al: A safe and highly effective measles virus-based vaccine expressing a stable previous elevation of SARS-CoV-2, in Proceedings of the National Academy of Sciences (veröffentlicht PNAS 23.03.2021), PNAS
- Ohio State University: Leveraging the successful history of the measles vaccine to protect against SARS-CoV-2 (veröffentlicht 09.03. Ohio State University
This article is for general guidance only and is not intended to be used for self-diagnosis or self-medication. He cannot replace a visit to the doctor.