The main article on Alzheimer's disease will be withdrawn

This article is very popular because it relaunched one of the majority hypotheses to explain the occurrence of this disease, namely amyloid cascade. This hypothesis, developed by two American scientists in the early 1990s, states that the accumulation of a peptide called beta-amyloid causes a chain reaction with… finally Neuronal destruction and cognitive decline. When this article appeared 15 years later, In 2006 in the journal Naturetakes another step in his confirmation.

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The first American author of this article, who did the vast majority of the experiments, was a postdoctoral researcher of French origin, Sylvain Lesne, who is recognized for his research into Alzheimer's disease. In 2022, Investigation published in Science magazine Photo manipulation is suspected in this article. Finally, the work's lead researcher and final author, Karen Ash, has just accepted Last week to remove this article. What is this article's contribution to the amyloid hypothesis and what are the implications of withdrawing it? Answers with Luc Bui, Research Director of the Center National de la Recherche Scientifique, Head of the Inserm Laboratory “Alzheimer's and Tauopathy” and Director of the Center for Neuroscience and Cognitive Research in Lille.