Against the influence of gravity, it prevents and reverses the saccharification process

Isodon japonicus What is interesting is the ability of its leaves, which are thin and fragile, to reach a height of 2 meters. Its composition is characterized by the presence of lignin (and its precursors); Explaining its power and ability to defy the laws of gravity. We have designed a test sequence to demonstrate the anti-gravity ability of an extract obtained from the aerial parts ofIsodon japonicus : J-Dermist.

First, by focusing on the components of the dermal junction (DEJ) and extracellular matrix (ECM) of the skin, J-Dermist has shown a significant improvement in the synthesis of proteins that give the skin its biomechanical properties. These preliminary results were transferred to 3D experiments using X-Polar® technology applied to explants to visualize the structural benefits of collagen fibrils.

Analysis of the effect of J-Dermist on structural quality and collagen density using Kamax technology

Analysis of the structural quality of the ECM was evaluated using the Kamax technique which offers an innovative approach regarding the structure of collagen fibers.

To focus on both the spatial density and structural quality of fibres, Kamax technology uses polarized light contrasts (XPolar®) allowing accurate and complete analysis of samples. The birefringence of collagen bundles was studied at submicrometer resolution. In particular, the device provides a parameter (Kfs) that determines the spatial extent of the collagen network in a given field of view.

In our study, excised sections of human skin (49-year-old donor) were treated with topical applications of J-Dermist for 7 days and analyzed using Kamax technology.

J-Dermist significantly improves the integrity of collagen organization by +27% in the papillary dermis and +60% in the reticular dermis. This directly improves the quality of collagen fibers which can be interpreted as rejuvenation of collagen integrity.

On the other hand, J-Dermist significantly improves collagen density by +138% in the papillary dermis and +156% in the reticular dermis.

This analysis of the density and structural organization of collagen fibers in human skin extracts confirms that J-Dermist can help restore the density of the dermis, promote increased skin firmness, participate in the reduction of fine or deep wrinkles, and finally allow the skin to regenerate. Better resistance to gravity pressures.

Protective and restorative effect of J-Dermist on the breakdown of collagen fibers

Kamax technology also makes it possible to demonstrate the benefits of E J-Dermist on the integrity of collagen fibers exposed to sugar. J-Dermist is used before exposure to glycation and provides 100% protection of the integrity of collagen fibres. Used after the glycation process has begun, J-Dermist not only restores 100% of the integrity of the collagen fibers but also increases the quality of the fibers by +10% compared to explants that were not exposed to the glycation process.

Stady In vivo Wrinkles and gravitational stress

This study focuses on the wrinkles most clearly affected by gravity: nasolabial wrinkles. In fact, with age, the skin in the nasolabial area becomes less firm, more susceptible to the effects of gravity, and stretches without being able to retract, increasing the depth of wrinkles.

Thirty-five volunteers with visible nasolabial folds were recruited.

After 28 days of use, a significant reduction in roughness parameters was observed for the J-Dermist formula while no significant difference was observed with placebo.

Gravity pressure on the nasolabial folds can be visualized and measured by comparing the size of the nasolabial fold in the supine position (minimum gravitational pressure) and in the sitting position (maximum gravitational pressure). The difference in the size of the nasolabial fold between the sitting and lying positions represents the effect of gravity on tissue relaxation and thus on wrinkle depth.

After 28 days of treatment, we measured a greater reduction in gravitational pressure on nasolabial fold amplitude with J-Dermist compared to placebo, respectively -13% and -3%. If we consider the subjects (n = 15) most affected by gravitational stress, a significant -28% reduction in gravitational stress on the nasolabial fold amplitude was measured.

Conclusion

Directly inspired by the ability toIsodon japonicus To rise despite the influence of gravity. J-Dermist restores the structural properties of the skin to restore its ability to retract under the pressure of gravity. The use of innovative Kamax technologies allows us to better understand its mechanism of action, based not only on the quantity of supporting fibers but also on their structural quality as well as on the restructuring of the dermis-epidermis junction. J-Dermist visibly improves deep wrinkles while counteracting the effects of gravity to accentuate the signs of aging. This mechanism of action can also benefit other areas of the face such as the upper eyelids and facial features.